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US 2001/0056206 A1Published application
Process for the preparation of iopamidol
AssigneeBracco Imaging S.P.A.
InventorsRICHARD LORENZINI, ASHOK BHATIA, STEVE CHAMBERLIN, KEITH DRENGLER, JOHN HUFNAGEL, XIU WANG
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Abstract
The present invention discloses a process for the preparation of pure non-ionic contrast agents. The invention also includes a method for purifying the non-ionic contrast agents.
Claims20
A process for the preparation of a polyhydroxy compound and salts and enantiomers thereof, having formula I:
- 5
- wherein R1 and R2 are dihydroxyalkyl and R3 is hydrogen, alkyl, or hydroxy;
- said process comprising the step of deacylating an acylated compound having the formula:
- 6
- in an acidic medium,
- wherein R4 and R5 are acylated dihydroxyalkyl groups, and R6 is lower alkyl.
3 more elements
The process according to claim 6, wherein the acylated dihydroxyalkyl group is acylated with an acyl group selected from the group consisting of acetyl, propionyl, and butanoyl.
A compound and salts and enantiomers thereof, having the formula:
- 7
- wherein R7 is an acyl group.
Dependencies are inferred from the claim text.