Carboxylic acid derivatives as IP antagonists

A compound comprising Formula I:

• 41
• wherein:
• R1, R2, and R3 are each independently in each occurrence optionally substituted aryl or optionally substituted heteroaryl;
• R4 is —COOH or tetrazolyl;
• A is independently in each occurrence a single bond, —O(CH2)p—, —S(CH2)p—, —NR′(CH2)p—, —(CH2)pO—, —O(CH2)pO—, —(CH2)pO(CH2)p—, —(CH2)nCO(CH2)n—, —CON—, —NCO—;
• —(CH2)p—, —C═C—, or —C≡C—;
• B is independently in each occurrence —(CH2)q—, —CH2O—, —CH2S— or —CH2N—;
• m, p, and q are each independently in each occurrence an integer from 1 to 3 inclusive;
• n and r are each independently in each occurrence an integer from 0 to 3 inclusive;
• or an individual isomer, a racemic or non-racemic mixture of isomers, or a pharmaceutically acceptable salt or solvate thereof.