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US 2001/0056066 A1Published application
Method of treating immune cell mediated systemic diseases
AssigneeSmithKline Beecham Corporation
InventorsPeter John Bugelski, Charles Baldwin Davis, Brian Richard MacDonald
Life of this patent
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Abstract
An improved method of treating immune cell mediated systemic diseases, particularly T and B cell mediated diseases, is provided by increasing the systemic exposure, or bioavailibility, of a therapeutic protein. Such therapeutic protein is selected from the group consisting of a monoclonal antibody, a soluble receptor and a soluble ligand which binds to an antigen expressed on the surface of an immunce cell.
Claims33
An improved method for treating immune cell mediated diseases wherein the improvement comprises:
- administering a saturating dose of a therapeutic protein selected from the group consisting of a monoclonal antibody, a soluble receptor and a soluble ligand which binds to an antigen expressed on the surface of an immune cell;
- followed by a second administration of said therapeutic protein, wherein the second administration is given subcutaneously, and wherein the systemic exposure of said therapeutic protein from the second administration is at least 50% greater than the systemic exposure from a first, and equivalent, subcutaneous dose of the therapeutic protein.
Dependencies are inferred from the claim text.