US 2001/0055798 A1 · Process for the enzymatic resolution of lactams

Abstract

A method of separating enantiomeric lactam esters. The lactam esters are contacted with a biocatalyst, such as an enzyme or a microorganism, in a solution wherein only one enantiomer is selectively hydrolyzed to give the optically active isomer of the corresponding acid. The hydrolysis product is then separated from the unreacted lactam esters. The enzyme is then recycled for reuse in the next enzymatic resolution. The undesired isomer is also racemized and reused in the next enzymatic resolution.

Claims14

Dependent claims

A method of separating enantiomeric lactam esters comprising contacting the lactam esters with a biocatalyst in an aqueous solution, an organic solvent, or a mixture of organic and aqueous solvents wherein only one enantiomer is selectively hydrolyzed to give the optically active isomer of the corresponding acid, and separating the hydrolysis product from the unreacted lactam esters.

Dependencies are inferred from the claim text.

Facts

Application

09/876,199Filed 6 Jun 2001

Priority

16 Feb 1999

Published

27 Dec 2001

Term ends

Not estimatedThe source records don’t support an estimate.

Classification4 codes

C12P 17/10
Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms: nitrogen as only ring hetero atom
C12P 17/12
Nitrogen as only ring hetero atom: containing a six-membered hetero ring
C12P 41/005
By ester formation, lactone formation or the inverse reactions: by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
C12P
Fermentation or enzyme-using processes to synthesise a desired chemical compound or composition

Process for the enzymatic resolution of lactams

Life of this patent

Process for the enzymatic resolution of lactams

Life of this patent

Abstract

Claims14