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US 2001/0055790 A1Published application
Human Wnt7a polypeptides
AssigneeSmithKline Beecham Corporation
InventorsMichael Robert Barnes, Tania Tamson Testa
Life of this patent
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Abstract
Wnt-7a polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Wnt-7a polypeptides and polynucleotides in therapy, and diagnostic assays for such.
Claims10
An isolated polypeptide selected from the group consisting of:
- (a) an isolated polypeptide encoded by a polynucleotide comprising the sequence of SEQ ID NO:1;
- (b) an isolated polypeptide comprising a polypeptide sequence having at least 99% identity to the polypeptide sequence of SEQ ID NO:2;
- (c) an isolated polypeptide comprising the polypeptide sequence of SEQ ID NO:2;
- (d) an isolated polypeptide having at least 99% identity to the polypeptide sequence of SEQ ID NO:2;
- (e) the polypeptide sequence of SEQ ID NO:2;
- and
- (f) fragments and variants of such polypeptides in (a) to (e).
4 more elements
An isolated polynucleotide selected from the group consisting of:
- (a) an isolated polynucleotide comprising a polynucleotide sequence having at least 99.5% identity to the polynucleotide sequence of SEQ ID NO:1;
- (b) an isolated polynucleotide comprising the polynucleotide of SEQ ID NO:
- 1;
- (c) an isolated polynucleotide having at least 99.5% identity to the polynucleotide of SEQ ID NO:1;
- (d) the isolated polynucleotide of SEQ ID NO:
- 1;
- (e) an isolated polynucleotide comprising a polynucleotide sequence encoding a polypeptide sequence having at least 99% identity to the polypeptide sequence of SEQ ID NO:2;
- (f) an isolated polynucleotide comprising a polynucleotide sequence encoding the polypeptide of SEQ ID NO:2;
- (g) an isolated polynucleotide having a polynucleotide sequence encoding a polypeptide sequence having at least 99% identity to the polypeptide sequence of SEQ ID NO:2;
- (h) an isolated polynucleotide encoding the polypeptide of SEQ ID NO:2;
- (i) an isolated polynucleotide with a nucleotide sequence of at least 100 nucleotides obtained by screening a library under stringent hybridization conditions with a labeled probe having the sequence of SEQ ID NO:
- 1 or a fragment thereof having at least 15 nucleotides;
- (j) a polynucleotide which is the RNA equivalent of a polynucleotide of (a) to (i);
- or a polynucleotide sequence complementary to said isolated polynucleotide and polynucleotides that are variants and fragments of the above mentioned polynucleotides or that are complementary to above mentioned polynucleotides, over the entire length thereof.
11 more elements
Dependencies are inferred from the claim text.