Frnk proteins in the treatment of tumor cells
OwnerWilliam G. Cance, Li-Hui Xuinventors
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Abstract
A recombinant virus vector comprising a heterologous nucleic acid segment encoding FRNK protein (including active fragments thereof) operably linked to regulatory sequences directing expression of said FRNK protein in a cell susceptible to infection by said DNA virus vector is disclosed. Also disclosed is isolated mammalian FRNK protein, along with nucleic acids encoding the same and expression cassettes containing such nucleic acids. Methods of using the foregoing to induce the death of tumor cells are disclosed.
Claims24
A recombinant DNA virus vector comprising a heterologous DNA segment encoding FRNK protein operably linked to regulatory sequences directling expression of said FRNK protein in a cell susceptible to infection by said DNA virus vector.
Isolated mammalian FRNK protein.
An isolated DNA encoding mammalian FRNK protein.
A method of inducing apoptosis in cancer cells, comprising administering to said cells FRNK protein or an active fragment thereof an amount sufficient to induce apoptosis therein.
A method of treating cancer in a subject in need of such treatment, comprising administering to said subject a treatment effective amount of FRNK protein or an active fragment thereof.
A method of screening compounds for efficacy in inducing apoptosis in cancer cells, comprising:
- determining whether said compound specifically binds to FRNK or FAK;
- the binding of said compound to FRNK or FAK indicating said compound is useful in treating said proliferative disease.
Dependencies are inferred from the claim text.