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AssigneeOklahoma Medical Research Foundation
InventorsKenneth L. Hensley, Robert A. Floyd
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The present invention involves the use of desmethyl tocopherols such as gamma tocopherol for the protection of cardiovascular tissue from nitrative stress. While mechanisms other than scavenging of reactive nitrogen species may be involved, desmethyl tocopherols exhibit significant protection and may be utilized to treat or help prevent cardiovascular particularly arterial vascular disease. The desmethyl tocopherols may be administered dietarily or parenterally when a more direct dosage is desired. Both routes may be utilized together or separately to optimize therapeutic and prophylactic benefits. The lessening of damage induced by reactive nitrogen species leads to the lessening of arterial blockage in thrombosis.
A method of delaying or preventing cardiovascular disease which comprises the administration of an effective amount of at least one desmethyl tocopherol.
A method of delaying or preventing symptoms and consequences of cardiovascular disease which comprises the administration of an effective amount of gamma tocopherol.
A method of inhibiting cardiovascular damage resulting from thrombosis which comprises administration of an effective amount of at least one desmethyl tocopherol.
A method of inhibiting cardiovascular damage resulting from thrombosis which comprises the administration of an effective amount of gamma tocopherol.
A method of preserving mitochondrial function in cardiovascular tissue which comprises the administration of a safe and effective amount of gamma tocopherol.
A method of preserving mitochondrial function in cardiovascular tissue which comprises administration of an effective amount of at least one desmethyl tocopherol.
Dependencies are inferred from the claim text.