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AssigneeParker Hughes Institute
InventorsFatih M. Uckun, Elise A. Sudbeck, Marina Cetkovic, Ravi Malaviya, Xing-Ping Liu
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The invention provides novel JAK-3 inhibitors that are useful for treating leukemia and lymphoma. The compounds are also useful to treat or prevent skin cancer, as well as sunburn and UVB-induced skin inflammation. In addition, the compounds of the present invention prevent the immunosuppressive effects of UVB radiation, and are useful to treat or prevent autoimmune diseases, inflammation, and transplant rejection. The invention also provides pharmaceutical compositions comprising compounds of the invention, as well as therapeutic methods for their use.
A compound of formula I:
A pharmaceutical composition comprising a compound of formula I:
A pharmaceutical composition comprising 4-(4′-hydroxyl-phenyl)-amino-6,7-dimethoxyquinazoline;
A therapeutic method for treating leukemia or lymphoma in a mammal comprising administering to the mammal in need thereof an effective amount of a JAK-3 inhibitor.
A therapeutic method for treating or preventing organ transplant rejection in a mammal comprising administering to the mammal in need thereof an effective amount of a JAK-3 inhibitor.
A therapeutic method for preventing or reducing ultraviolet B radiation-induced inflammatory response in a mammal comprising administering to the mammal in need thereof an effective amount of a JAK-3 inhibitor.
A therapeutic method for inhibiting the release of prostaglandin E2 in a mammal comprising administering to the mammal in need thereof an effective amount of a JAK-3 inhibitor.
A therapeutic method for preventing or reducing UVB-induced skin edema or vascular permeability changes in a mammal comprising administering to the mammal in need thereof an effective amount of a JAK-3 inhibitor.
A therapeutic method for preventing or reducing ultraviolet B radiation-induced damage to epithelial cells or mutation frequency in skin in a mammal comprising administering to the mammal in need thereof an effective amount of a JAK-3 inhibitor.
A therapeutic method for protecting a mammal from tumorigenic effects of UVB light comprising administering to the mammal in need thereof an effective amount of a JAK-3 inhibitor.
A therapeutic method for inhibiting T-cell activity in a mammal comprising administering to the mammal in need thereof an effective amount of a JAK-3 inhibitor.
A therapeutic method for preventing or treating an autoimmune disease comprising administering to the mammal in need thereof an effective amount of a JAK-3 inhibitor.
A therapeutic method for preventing or treating graft-verses host disease comprising administering to the mammal in need thereof an effective amount of a JAK-3 inhibitor.
Dependencies are inferred from the claim text.