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AssigneesThe Regents of the University of California, The Scripps Research Institute
InventorsM. Reza Ghadiri, Michael J. Sailor, Kianoush Motesharei, Shang-Yi Lin, Keiki-Pua S. Dancil
Estimating the term…
The measurement of the wavelength shifts in the reflectometric interference spectra of a porous semiconductor substrate such as silicon, make possible the highly sensitive detection, identification and quantification of small analyte molecules. The sensor of the subject invention is effective in detecting multiple layers of biomolecular interactions, termed “cascade sensing”, including sensitive detection of small molecule recognition events that take place relatively far from the semiconductor surface.
A process for detecting an analyte in a sample to be assayed comprising the steps of:
A process for detecting an organic molecule analyte in a sample to be assayed comprising the steps of:
A process of quantitatively detecting organic analyte molecules in a sample comprising the steps of:
In a solid state sensor for detecting Fabry-Perot fringes from the reflection of light from a semiconductor substrate, the improvement comprising a semiconductor substrate having a porous surface, said substrate surface having an organic binder compound adsorbed thereon.
A reflective sensor comprising a semiconductor substrate having a porous surface area, said substrate surface area having an organic binder compound intimately associated thereon, said binder compound binding selectively with said analyte.
A reflective sensor for an analyte comprising a layer of porous semiconductor with a binder compound for the analyte intimately associated therewith, said layer being substantially transparent and having a top surface and a bottom surface which reflect light to exhibit Fabry-Perot fringes having a first set of characteristic wave lengths in the absence of analyte and a second set of characteristic wave lengths when analyte is present, said second set of characteristic wave lengths being detectably shifted from said first set of characteristic wavelengths.
An analytical sensor for detecting a target species comprising a porous semiconductor layer of a thickness selected to generate Fabry-Perot fringes from the reflection of light therefrom, said Fabry-Perot fringes having a first set of characteristic peak wavelengths in the absence of the target species and a second set of characteristic peak wavelengths in the presence of the target species with the second set of peak wave lengths being shifted toward shorter wavelengths relative to said first set of wavelengths.
A process for detecting a target species in a sample to be assayed comprising the steps of
A reflective sensor array for at least one analyte comprising a layer of porous semiconductor with a plurality of discrete and separate regions having one or more binder compounds for at least one of the at least one analytes intimately associated therewith, said layer being substantially transparent and having a top surface and a bottom surface which reflect light in each of the plurality of regions to exhibit Fabry-Perot fringes for such regions having a first set of characteristic wave lengths in the absence of the at least one analyte and a second set of characteristic wave lengths when analyte is present, said second set of characteristic wave lengths being detectably shifted from said first set of characteristic wavelengths.
Dependencies are inferred from the claim text.