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AssigneeThe Regents of the University of California
InventorsMark H. Tuszynski, Armin Blesch
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The invention provides a clinically useful protocol for delivery of recombinant nervous system growth factors into the aging mammalian brain. The invention is particularly useful in tempering and reversing the loss of neurological function in the aging mammalian brain, by (a) correlating loss of cortical fiber density to impairment of neurological function in the normal, aging brain; and (b) providing minimally invasive means by which such losses may be reversed. To these ends, a method is provided by which a growth factor-encoding transgene is delivered to, and expressed in, preselected sites within the brain, to stimulate growth of neurons at, and at a distance from, each delivery site.
A method for ameliorating neuronal atrophy and loss accompanying normal aging in the mammalian brain, the method comprising delivering a unit dosage of a growth factor-encoding transgene composition to preselected delivery sites in the brain, wherein the encoded growth factor is expressed in the brain, and stimulates axonal growth in targeted growth factor-receptive neurons therein.
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