Method and compositions for detection and diagnosis of infectious diseases
AssigneeJapan BCG Laboratory
InventorReiko M. Nakamura
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Abstract
Methods and compositions for the detection and diagnosis of infectious diseases are provided. In particular, efficient and sensitive methods and compositions for the detection of active mycobacterial disease are provided for distinguishing between individuals having active disease, and individuals who have been immunologically exposed, such as those infected with a mycobacterium but are without active disease, or those who have been vaccinated with BCG. The methods comprise topical application of antigen compositions for transdermal delivery.
Claims20
A transdermal delivery device for diagnosing infectious disease comprising topical application of a composition comprising antigen and physiologically effective solution.
A method of detecting active disease comprising,
- topically applying a transdermal delivery device to skin, wherein said device comprises an antigen composition;
- removing said transdermal delivery device after a predetermined period of time;
- observing the skin for an immune response;
- and
- correlating the presence of the immune response with active disease.
An composition for detecting infectious disease comprising,
- an antigen, and
- a physiologically effective solution for transdermal delivery following topical application.
Dependencies are inferred from the claim text.