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US 2001/0041892 A1Published application
Hemofiltration system including ultrafiltrate purification and re-infusion system
AssigneeNxStage Medical, Inc.
InventorsJEFFREY H. BURBANK, C. DAVID FINCH, JAMES M. BRUGGER
Life of this patent
Estimating the term…
Abstract
A hemofiltration system is provided in which ultrafiltrate is purified by reverse osmosis for reinfusion. Non-sterile infusate concentrate is dialyzed into the purified ultrafiltrate and combined with cleared blood which is returned to the patient. In another system, a hemofilter is used to sterilize essentially pure, non-sterile water for dilution of sterile infusate concentrate, then the hemofilter is used to filter blood, the infusate concentrate being combined with cleared blood for return to the patient.
Claims74
A method comprising:
- purifying bloodstream waste of a patient to form essentially pure water;
- sterilizing a non-sterile infusate additive to form a patient-sterile infusate additive;
- and
- combining the essentially pure water and the patient-sterile infusate additive to form an infusate solution suitable for introduction into the bloodstream of the patient.
1 more element
A system comprising:
- a semipermeable membrane unit for use with a patient including a semipermeable membrane having a patient-sterile side and a non-sterile side;
- a water purification unit including an inlet for receiving impure water and an outlet for delivering purified water, constructed and arranged to purify water between the inlet and the outlet;
- and
- a fluid conduit connecting the outlet of the water purification unit with the sterile side of the semipermeable membrane of the semipermeable membrane unit.
1 more element
A method comprising:
- dialyzing a nonsterile infusate additive into a fluid across a semipermeable membrane across which net ionic flow into the fluid occurs to form an infusate solution suitable for introduction into a patient without further treatment.
A system comprising:
- a semipermeable membrane unit for use with a patient including a semipermeable membrane having a patient-sterile side and a non-sterile side, the patient-sterile side in fluid communication with a patient-sterile conduit connectable to a fluid system of the patient;
- and
- fluid circuitry associated with the semipermeable membrane unit, constructed and arranged to provide osmotic pressure driving net ionic transport across the semipermeable membrane from the non-sterile side to the patient-sterile side.
A method comprising:
- combining a fluid infusate output from a semipermeable membrane unit, including a membrane across which net ionic flow occurs into the infusate, with a fluid output from a blood purification device to provide an infusate solution suitable for introduction into a bloodstream of a patient.
A system comprising:
- a semipermeable membrane unit for use with a patient including a semipermeable membrane having a patient-sterile side and a non-sterile side;
- a blood purification device having a conduit fluidly connectable to the patient's bloodstream for delivering cleared blood to the patient;
- a fluid conduit allowing connection between the patient-sterile side of the semipermeable membrane and the fluid conduit of the blood purification device;
- and
- fluid circuitry associated with the semipermeable membrane unit, constructed and arranged to provide osmotic pressure driving net ionic transport across the semipermeable membrane from the non-sterile side to the patient-sterile side.
2 more elements
A method comprising:
- passing essentially pure, nonsterile water through an ultrafiltration membrane to form essentially pure, sterile water,
- adding the essentially pure, sterile water to an infusate concentrate to form an infusate solution;
- and
- passing impure blood through the ultrafiltration membrane thereby removing ultrafiltrate waste through the membrane and recovering from the membrane cleansed blood.
1 more element
A system comprising:
- a semipermeable membrane, one side of which is in fluid communication with an infusate concentrate and is connectable fluidly with a bloodstream of a patient without making or breaking conduit connections.
A method comprising:
- creating an infusion solution suitable for introduction into a patient by allowing a non-sterile infusate additive to diffuse across an semipermeable membrane separating a first, non-sterile chamber of a container, within which the infusate additive is contained, from a second, sterile chamber of the container containing sterile fluid.
An article comprising:
- a container defining an impermeable interior wall, separated into a first chamber and a second chamber by an semipermeable membrane, the first chamber, including a first side of the semipermeable membrane, being non-sterile and a second chamber, including a second-side of the semipermeable membrane, being sterile.
A method comprising:
- dialyzing an infusate additive into a fluid stream across a semipermeable membrane across which net ionic flow into the fluid stream occurs to form an infusate solution suitable for introduction into a bloodstream of a patient;
- and
- introducing the infusate solution into the bloodstream of the patient.
A method comprising:
- passing a fluid stream through a semipermeable membrane unit and, within the semipermeable membrane unit, adding an infusate additive to the fluid stream to form an infusate solution suitable to be introduced into a bloodstream of a patient without removing solutes from the fluid stream.
A system comprising:
- a semipermeable membrane unit including a semipermeable membrane having a first side and a second side, the first side in fluid communication with a conduit connectable to a bloodstream of a patient;
- and
- fluid circuitry associated with the semipermeable membrane unit, constructed and arranged to provide osmotic pressure driving ionic transport across the semipermeable membrane from the non-sterile side to the sterile side.
A method comprising:
- maintaining a concentration gradient across a semipermeable membrane of a semipermeable membrane unit across which diffusion occurs from a first side to a second side by feeding fluid of a first, elevated concentration to the first side from a constant-volume fluid enclosure while removing from the first side to the constant-volume fluid enclosure fluid of a second concentration lower than the first concentration.
A system comprising:
- a semipermeable membrane unit including a semipermeable membrane having a first side and a second side;
- an enclosure having an inlet and an outlet, both fluidly connectable to the first side of the semipermeable membrane unit membrane, and a movable, nonporous barrier within the enclosure sealingly separating the inlet from the outlet.
A system comprising:
- a semipermeable membrane unit including a semipermeable membrane having a first side and a second side, and an enclosure surrounding the first side having an inlet and an outlet constructed and arranged to receive fluid from the inlet for contact with the first side and to discharge fluid from the first side through the outlet;
- a first sealed fluid container in fluid communication with the inlet;
- and
- a second sealed fluid container in fluid communication with the outlet.
1 more element
A method of monitoring a solution, comprising:
- dialyzing an infusate additive into a fluid stream to provide an infusate solution having a conductivity;
- and measuring the conductivity of the infusate solution.
A method of purifying a solution, comprising:
- contacting a fluid stream in need of filtration with a first side of a filter to form a first contacted stream that passes through the filter and a second contacted stream that does not pass through the filter;
- and
- recirculating the second contacted stream to the first side of the filter by passing the second stream through a recirculation conduit including a receptacle having a variable volume;
- adding an amount of the second contacted stream to the expandable bag so that an amount of the second stream that is recirculated to the first side of the filter is constant and adding the second contacted stream to the fluid stream in need of filtration.
1 more element
A method of purifying a fluid, comprising:
- establishing a stream of a fluid directed toward a filter having an upstream side and a downstream side, the stream containing a species;
- passing a first portion of the stream of fluid through the filter, free of the species, while maintaining a second portion of the fluid, containing the species, on the upstream side of the filter;
- diverting the second portion of the stream from the filter through a recirculation conduit including a receptacle having a variable volume;
- and
- recirculating the second portion of the fluid stream by adding the second portion to the stream of a fluid directed toward a filter.
2 more elements
Dependencies are inferred from the claim text.