Process for the preparation of N-carboxy-t-leucine anhydride
AssigneeDsm N.V.
InventorsRobert P. Hof, Wilhelmus Zwaan
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Abstract
Process for the preparation of N-carboxy-t-leucine anhydride in which the corresponding N-carboxy-t-leucine is subjected to a cyclization with the aid of an acyl halogenide. Preferably, acetyl chloride is used as acyl halogenide. The N-carboxy-t-leucine anhydride obtained optionally is subsequently converted into a t-leucine-N-substituted amide with the aid of the corresponding amine. Preferably, methyl amine is chosen as the amine, and the reaction is carried out in a mixture of water and methanol as solvent.
Claims9
A process for the preparation of an N-carboxy-t-leucine anhydride in which N-carboxy-t-leucine is subjected to a cyclization with the aid of an acyl halogenide.
A process for the preparation of a N-carboxy-t-leucine anhydride in which N-carboxy-t-leucine is subjected to a cyclization with the aid of acetylchloride, in which process the amount of acetylchloride to be used ranges from 1.05 to 1.2 equivalents calculated relative to the amount of N-carboxy-t-leucine and in which the reaction is carried out at a temperature between 0 and 150° C.
Dependencies are inferred from the claim text.