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US 2001/0041743 A1Published application
Use of cyclopentenone derivatives for bone and periodontal regeneration
OwnerSteven Offenbacher, Lyndon F. Cooper +1inventors
InventorsSteven Offenbacher, Lyndon F. Cooper, Michael E. Fritz
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Abstract
Methods for bone and periodontal tissue regeneration using cyclopentenone prostanoids and their agonists, and methods to retard pathophysiological calcification using cyclopentenone antagonists.
Claims26
A method of stimulating bone growth, the method comprising:
- (a) preparing a composition comprising a cyclopentenone compound, a cyclopentenone related compound, a cyclopentenone modulator, or combinations thereof, and a carrier;
- and
- (b) administering the composition of (a) to a subject, whereby bone growth is stimulated.
A therapeutic composition for bone repair comprising:
- (a) a cyclopentenone, cyclopentenone related compound, or cyclopentenone regulator;
- and
- (b) an implantable pharmaceutically acceptable carrier.
A method for identifying a cyclopentenone modulator, the method comprising:
- (a) providing a cyclopentenone or cyclopentenone related compound;
- (b) exposing the cyclopentenone or cyclopentenone related compound to a plurality of candidate modulators;
- and
- (c) selecting a candidate regulator that demonstrates specific binding to the cyclopentenone or cyclopentenone related compounds, whereby a cyclopentenone modulator is identified.
1 more element
Dependencies are inferred from the claim text.