Polyunsaturated fatty acid derivatives and their use
AssigneeArdenia Investments, Ltd.
InventorOleg Strelchenok
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Abstract
Novel amides are disclosed, in particular amides of the all-trans-retinoic acid or 13-cis-retinoic acid and arachidonic acid and docosahexaenoic acid and eicosapentaenoic acid or linoleic acid with 2-aminoethanol, alpha-L-serine, alpha-L-threonine, alpha-L-tyrosine containing phosphate groups. Further, the present invention discloses the synthesis and use of these compounds, in particular their pharmaceutical application.
Claims24
A compound selected from the following group:
- N-linolenoyl-o-phospho-2-aminoethanol
- N-linolenoyl-o-phospho-L-serine
- N-linolenoyl-o-phospho-L-threonine
- N-linolenoyl-o-phospho-L-tyrosine.
A compound selected from the following group:
- N-docosahexaenoyl-o-phospho-2-aminoethanol
- N-docosahexaenoyl-o-phospho-L-serine
- N-docosahexaenoyl-o-phospho-L-threonine
- N-docosahexaenoyl-o-phospho-L-tyrosine.
A compound selected from the following group:
- N-eicosapentaenoyl-o-phospho-2-aminoethanol
- N-eicosapentaenoyl-o-phospho-L-serine
- N-eicosapentaenoyl-o-phospho-L-threonine
- N-eicosapentaenoyl-o-phospho-L-tyrosine.
A compound selected from the following group:
- N-arachidonoyl-o-phospho-2-aminoethanol
- N-arachidonoyl-o-phospho-L-serine
- N-arachidonoyl-o-phospho-L-threonine
- N-arachidonoyl-o-phospho-L-tyrosine.
Use of a compound according to claim 1 for the manufacture of a medicament.
Use of a compound according to claim 2 for the manufacture of a medicament.
A pharmaceutical composition, characterized in that said composition comprises as an active ingredient at least one compound according to claim 1.
A pharmaceutical composition, characterized in that said composition comprises as an active ingredient at least one compound according to claim 2.
Process for the preparation of a compound according to claim 1.
Process for the preparation of a compound according to claim 2.
Dependencies are inferred from the claim text.