Self-emulsifying systems containing anticancer medicament
AssigneeAbbott Laboratories
InventorsRong Ron Liu, Zheng Wang
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Abstract
The present invention relates to a stabilized self-emulsifying system, comprising a therapeutically effective amount of o-(chloroacetylcarbamoyl)fumigillol, a pharmaceutically acceptable carrier and a stabilizing component, wherein the pharmaceutically acceptable carrier comprises an oily constituent and at least one surfactant. The stabilizing component comprises from about 1% to about 15% water relative to the weight of the self-emulsifying system, an acid, an adsorbent, or a complex-forming agent.
Claims32
A stabilized self-emulsifying system, comprising a therapeutically effective amount of o-(chloroacetylcarbamoyl)fumigillol, a pharmaceutically acceptable carrier and a stabilizing component, wherein the pharmaceutically acceptable carrier comprises an oily constituent and at least one surfactant and the stabilizing component comprises from about 1% to about 15% water relative to the weight of the stabilized self-emulsifying system.
A stabilized self-emulsifying system, comprising a therapeutically effective amount of o-(chloroacetylcarbamoyl)fumigillol, a pharmaceutically acceptable carrier and a stabilizing component, wherein the pharmaceutically acceptable carrier comprises an oily constituent and at least one surfactant and the stabilizing component comprises an acid.
A stable drug system comprising a therapeutically effective amount of o-(chloroacetylcarbamoyl)fumigillol, a pharmaceutically acceptable carrier and a stabilizing component, wherein the pharmaceutically acceptable carrier comprises an oily constituent and at least one surfactant and the stabilizing component is an adsorbent or complex-forming agent.
A pharmaceutical composition comprising a therapeutically active amount of o-(chloroacetylcarbamoyl)fumigillol, an oily constituent, at least one surfactant, and stabilizing component, wherein the stabilizing component is selected from about 1 to about 15 weight percent water;
- from about 0.005 to about 5.0 weight percent acid;
- and 0.05 to about 15 weight percent of an adsorbent or complex-forming agent.
Dependencies are inferred from the claim text.