Water-wettable chromatographic media for solid phase extraction
AssigneeWaters Corporation
InventorsEdouard S. P. Bouvier, Randy E. Meirowitz, Patrick D. McDonald
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Abstract
A method for removing an organic solute from a solution, comprising contacting the solution with a polymer formed by copolymerizing one or more hydrophobic monomers and one or more hydrophilic monomers, whereby the solute is adsorbed onto the polymer. The solution can comprise a polar solvent such as a polar organic solvent or water or an aqueous buffer. The hydrophobic monomer can be, for example, divinylbenzene. The hydrophilic monomer can be, for example, a heterocyclic monomer, such as a vinylpyridine or N-vinylpyrrolidone.
Claims20
A solid phase extraction cartridge comprising a water-wettable polymer packed inside an open-ended container, said polymer being formed by copolymerizing at least one hydrophobic monomer and at least one hydrophilic monomer having a hydrophilic to hydrophobic monomer ratio sufficient for the polymer to be water-wettable while being effective to retain organic solutes over a range of chromatographic polarities and wherein the polymer comprises greater than at least 12 mole percent of hydrophilic monomer.
The solid phase extraction cartridge of claim I wherein the hydrophilic monomer comprises a heterocyclic group.
A microtiter well plate suitable for extraction comprising a water-wettable polymer packed inside an open-ended container, said polymer being formed by copolymerizing at least one hydrophobic monomer and at least one hydrophilic monomer having a hydrophilic to hydrophobic monomer ratio sufficient for the polymer to be water-wettable and wherein the polymer comprises greater than at least 12 mole percent of hydrophilic monomer.
Dependencies are inferred from the claim text.