Ocular analyte sensor
AssigneeNovartis AG
InventorWayne Front March
Life of this patent
Estimating the term…
Abstract
An ophthalmic lens comprising a receptor moiety can be used to determine the amount of an analyte in an ocular fluid. The receptor moiety can bind either a specific analyte or a detectably labeled competitor moiety. The amount of detectably labeled competitor moiety which is displaced from the receptor moiety by the analyte is measured and provides a means of determining analyte concentration in an ocular fluid, such as tears, aqueous humor, or interstitial fluid. The concentration of the analyte in the ocular fluid, in turn, indicates the concentration of the analyte in a fluid or tissue sample of the body, such as blood or intracellular fluid.
Claims53
An ophthalmic lens for detecting an analyte in an ocular fluid, comprising:
- a receptor moiety which comprises an analyte/competitor moiety binding site.
An ophthalmic lens for detecting glucose in an ocular fluid, comprising:
- a receptor moiety layer, wherein receptor moieties in the receptor moiety layer comprise glucose/competitor moiety binding sites;
- a first and a second polyelectrolyte layer;
- and
- a competitor moiety layer, wherein competitor moieties in the competitor moiety layer comprise detectable labels.
An analyte sensor system, comprising:
- (a) an ophthalmic lens for detecting an analyte in an ocular fluid, comprising:
- (i) a receptor moiety which comprises an analyte/competitor moiety binding site;
- and
- (ii) a competitor moiety comprising a detectable label;
- and
- (b) a detector configured to detect the detectable label.
A method for measuring the concentration of an analyte in an ocular fluid, comprising the steps of:
- (a) contacting the ocular fluid with an ophthalmic lens, wherein the ophthalmic lens comprises:
- (i) a receptor moiety which comprises an analyte/competitor moiety binding site;
- and
- (ii) a competitor moiety which comprises a detectable label;
- and
- (b) detecting the detectable label, wherein the amount of detectable label detected indicates the concentration of the analyte in the ocular fluid.
A method for varying the concentration of an analyte in an ocular fluid, comprising the steps of:
- (a) contacting the ocular fluid with an ophthalmic lens, wherein the ophthalmic lens comprises:
- (i) a competitor moiety which comprises a detectable label;
- and
- (ii) a receptor moiety which comprises an analytelcompetitor moiety binding site;
- (b) detecting the detectable label, wherein the amount of detectable label detected indicates the concentration of the analyte in a body tissue or fluid;
- (c) transmitting a signal indicating the concentration of the analyte in the ocular fluid to a pump configured to vary the concentration of the analyte in the body tissue or fluid;
- and
- (d) providing a regulator moiety via the pump to the body tissue or fluid, whereby the concentration of the analyte in the body tissue or fluid is varied.
A kit for detecting an analyte in an ocular fluid, comprising:
- an ophthalmic lens comprising a receptor moiety which comprises an analyte/competitor moiety binding site;
- and
- instructions for using the ophthalmic lens to detect the analyte.
A kit for detecting glucose in an ocular fluid, comprising:
- a contact lens comprising concanavalin A and fluorescein dextran;
- and instructions for using the contact lens to detect glucose in the ocular fluid.
Dependencies are inferred from the claim text.