Crystalline trehalose dihydrate, its preparation and uses
AssigneeKabushik Kaisha Hayashibara Seibuts Kagaku Kenkyujo
InventorsTetsuya Ohashi, Hiroto Chaen, Toshio Miyake
Life of this patent
Estimating the term…
Abstract
Disclosed are a crystalline trehalose dehydrate which has an elongated crystalline structure with a proportion of the length in the c axis to that in the b axis less than 2.0, its preparation and uses. The crystal has insubstantial hygroscopicity and solidification, and satisfactory stability, free-flowing ability, and handleability; it can be easily processed without fracture in the drying and sieving steps.
Claims7
A process for producing crystalline trehalose dihyrdrate having an elongated crystalline structure with a proportion of the length in the c axis to that in the b axis being less than 2.0, which process comprises:
- placing in a crystallizer a supersaturated aqueous trehalose solution with a trehalose content of at least 98 w/w %, on a dry solid basis;
- coexisting a crystalline trehalose dihydrate as a seed crystal;
- growing the crystalline trehalose dihydrate by cooling the mixture gradually to control the supersaturation degree to a level of less than 1.15;
- and
- separating and drying the resulting mixture to collect the grown crystalline trehalose dihydrate.
A process for producing a composition, which process comprises
- incorporating a crystalline trehalose dihydrate having an elongated crystalline structure with a proportion of the length in the c axis to that in the b axis of less than 2.0, and with a length in the c axis of at least 3 mm, into a material product, wherein said crystalline trehalose dehydrate is producible by:
- placing in a crystallizer a supersaturated aqueous trehalose solution with a trehalose content of at least 98 w/w %, on a dry solid basis;
- coexisting a crystalline trehalose dihydrate as a seed crystal;
- growing the crystalline trehalose dihydrate by cooling the mixture gradually to control the supersaturation degree to a level of less than 1.15;
- and
- separating and drying the resulting mixture to collect the grown crystalline trehalose dihydrate.
A method for growing crystalline trehalose dihydrate which has an elongated crystalline structure with a proportion of the length of the c axis to that of the b axis being less than 2.0, the c axis having a length of at least 3 mm, which process comprises:
- placing in a crystallizer a supersaturated aqueous trehalose solution with a trehalose content of at least 98 w/w %, on a dry solid basis;
- coexisting a crystalline trehalose dihydrate as a seed crystal;
- and
- growing the crystalline trehalose dihydrate by cooling the mixture gradually to control the supersaturation degree to a level of less than 1.15.
Dependencies are inferred from the claim text.