Sustained release oral formulations
OwnerJorg Ogorka, Oskar Kalb +2inventors
InventorsJorg Ogorka, Oskar Kalb, Rajen Shah, Satish Chandra Khanna
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Abstract
Pharmaceutical composition capable of releasing a therapeutically effective dose of active agent, e.g., rivastigamine, in a time-controlled manner.
Claims31
A pharmaceutical composition comprising
- a first component comprising a first active agent dose wherein on contact with water 70 to 95% of said dose is released within 3 to 4 hours, and
- a second component comprising a second active agent dose, a water soluble osmosis inducing agent and a water swellable excipient, said second component having a water permeable coating which, in use on contact with water, ruptures after a delay, and releases the active agent.
A pharmaceutical composition comprising rivastigmine adapted so that in use on oral administration a therapeutically effective dose of rivastigmine is released only after 6 hours.
A pharmaceutical composition capable of releasing on administration twice a therapeutically effective dose of rivastigmine at different intervals upon oral administration.
A pharmaceutical oral controlled release tablet composition comprising rivastigmine.
A pharmaceutical composition comprising Rivastigmine having the following release characteristics in water:
- 29 time (minutes) amount (percentage) 30 1-40 60 10-60 120 40-80 180 60-90 240 65-95 300 70-99 360 75-99 420 >80.
A controlled release, oral pharmaceutical composition containing rivastigmine having the following release characteristic in water or artificial stomach juices:
- 30 time (minutes) amount (percentage) 30 1-8 60 15-25 120 45-70 180 75-90 240 92-95 300 95-98 360 97-99 420 >99.
A controlled release, oral pharmaceutical composition containing rivastigmine having the following release characteristic in water or artificial stomach juices:
- 31 time (minutes) amount (percentage) 30 5-25 60 25-45 120 50-70 180 65-80 240 70-90 300 75-95 360 80-90 420 85-95 480 85-95.
A controlled release, oral pharmaceutical composition containing rivastigmine having the following release characteristic in water or artificial stomach juices:
- 32 time (minutes) amount (percentage) 30 25-40 60 45-65 120 65-85 180 75-95 240 75-96 300 85-97 360 87-98 420 90-98 480 90-99.
A controlled release, oral pharmaceutical composition containing rivastigmine wherein in use 50 to 80% of said rivastigmine is released in artificial stomach juices within 3 hours.
A pharmaceutical oral controlled release tablet composition comprising rivastigmine having the following release characteristic in water or artificial stomach juices:
- 33 time (minutes) amount (percentage) 30 28-35 60 40-55 120 58-75 180 70-90 240 80-95 300 88-98 360 >92.
A pharmaceutical oral controlled release tablet composition comprising rivastigmine wherein in use 60 to 90% of said rivastigmine is released in artificial stomach juices within 3 hours.
A pharmaceutical composition comprising a core coated with two films, the first inner film being a semi-permeable to water or body fluids film applied directly on said core and comprising cellulose acetate, the second outer film being a permeable to water or body fluids film comprising ethylcellulose.
Dependencies are inferred from the claim text.