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US 2001/0031753 A1Published application
Process for the preparation of substituted benzophenones
AssigneeBASF SE
InventorVenkataraman Kameswaran
Life of this patent
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Abstract
There is provided an efficient and effective process for the preparation of a compound of formula I (I) 1 via the acylation of the appropriate substituted benzene substrate in the presence of graphite, optionally in the presence of FeCl3. Compounds of formula I are useful as intermediates in the manufacture of agrichemical agents.
Claims10
A process for the preparation of a compound of formula I
- 27
- wherein m and n are each independently 0 or an integer of 1, 2, 3, 4 or 5;
- R is halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6-alkoxy,C1-C6alkoxyalkyl, CO2R1, S(O)pR2, NR3R4, NO2 or CN;
- R′ is C1-C6alkyl, C1-C6alkoxy, C1-C6alkoxyalkyl, or NR5R6;
- R1, R2, R3, R4, R5 and R6 are each independently C1-C6 alkyl;
- and
- p is 0 or an integer of 1 or 2
- which process comprises reacting a compound of formula II
- 28
- wherein Q is CX3 or COX;
- X is Cl or Br;
- and R and m are as described hereinabove with at least one molar equivalent of a compound of formula III
- 29
- wherein R′ and n are as described hereinabove in the presence of graphite and an inert solvent, optionally in the presence of FeCl3, and when Q is CX3 in the presence of at least one molar equivalent of water.
11 more elements
A process for the preparation of a fungicidal compound of formula IV
- 30
- wherein m and n are each independently 0 or an integer of 1, 2, 3, 4 or 5;
- R is halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6alkoxyalkyl, CO2R1, S(O)pR2, NR3R4, NO2 or CN;
- R′ is C1-C6alkyl, C1-C6alkoxy, C1-C6alkoxyalkyl, or NR5R6;
- R1, R2, R3, R4, R5 and R6 are each independently C1-C6alkyl;
- and
- p is 0 or an integer of 1 or 2
- which process comprises reacting a compound of formula II
- 31
- wherein Q is CX3 or COX;
- X is Cl or Br;
- and R and m are as described hereinabove with at least one molar equivalent of a compound of formula III
- 32
- wherein R′ and n are as described hereinabove in the presence of graphite and an inert solvent, optionally in the presence of FeCl3, and when Q is CX3 in the presence of at least one molar equivalent of water to form a compound of formula I
- 33
- wherein m, n, R and R′ are as described hereinabove, and reacting said formula I compound with N-acetylmorpholine in the presence of sodium tert-alkoxide, optionally in the presence of a solvent, to give the desired fungicidal formula IV product.
13 more elements
Dependencies are inferred from the claim text.