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US 2001/0027215 A1Published application
Compositions and administration of compositions for the treatment of blood disorders
AssigneeSusan Perrine
InventorSusan P. Perrine
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AssigneeSusan Perrine
InventorSusan P. Perrine
Estimating the term…
The invention relates to novel compositions and to methods for the pulsed administration of compositions to a patient or to cells in vitro for the treatment of human blood disorders. Compositions contain chemical compounds that stimulate the expression of fetal hemoglobin and/or stimulate the proliferation of red blood cells, white blood cells and platelets in patients and ex vivo for reconstitution of hematopoiesis in vivo. These methods are useful to treat or prevent the symptoms associated with anemia, sickle cell disease, thalassemia, blood loss, and other blood disorders. The invention also relates to methods for the pulsed administration of compositions to patients for the treatment and prevention of cell proliferative disorders including deficiencies such as cytopenia and malignancies and for expansion of cells for hematopoietic transplantation. Pulsed administration has been shown to be more effective than continuous therapy in patients tested.
A method for treating a human cell proliferative disorder by stimulating cell growth, comprising administering to a patient in need a pharmaceutically effective amount of a composition containing an effective amount of a C1-C4 substituted and/or phenyl substituted carboxylic acid and pharmaceutically acceptable salts thereof, and a pharmaceutically acceptable carrier or diluent, wherein said C1-C4 moiety and said phenyl moiety can be substituted or unsubstituted, wherein said substituents are selected from the group consisting of hydroxy, halogens, phenyl, thiol, mercapto and methylthiol.
A method of reducing the amount of a growth stimulating compound that must be administered to a patient having a cell proliferative disorder comprising administering an effective amount of a composition containing a C1-C4 substituted and/or phenyl substituted compound, wherein said compound is selected from the group consisting of cinnamic acid, acetic acid, butyric acid and propionic acid, or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier or diluert, wherein said C1-C4 moiety and said phenyl moiety can be substituted or unsubstituted, and said substituents are selected from the group consisting of hydroxy, halogens, phenyl, thiol, mercapto and methyl thiol.
Dependencies are inferred from the claim text.