3-(4'-bromobenzylindenyl)-2-indolinone and analogues thereof for the treatment of disease

A compound having the formula:

• 11
• and pharmaceutically acceptable salts thereof, wherein:
• R1 is H or alkyl;
• R2 is O or S;
• R3 is hydrogen;
• R4, R5, R6 and R7 are each independently selected from the group consisting of hydrogen, alkyl, alkoxy, aryl, aryloxy, alkaryl, alkaryloxy, halogen, trihalomethyl, S(O)R, SO2NRR′, SO3R, SR, NO2, NRR′, OH, CN, C(O)R, OC(O)R, NHC(O)R, (CH2)nCO2R, and CONRR′;
• R2′, R3′, R5′, and R6′ are each independently selected from the group consisting of hydrogen, alkyl, alkoxy, aryl, aryloxy, alkaryl, alkaryloxy, halogen, trihalomethyl, S(O)R, SO2NRR′, SO3R, SR, NO2, NRR′, OH, CN, C(O)R, OC(O)R, NHC(O)R, (CH2)nCO2R, and CONRR′;
• n is 0-3;
• Z is Br, Cl, F, I, methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, or tert-butyl;
• R is H, alkyl or aryl;
• and
• R′ is H, alkyl or aryl.