Colonic drug delivery composition
AssigneeWest Pharmaceutical Services Drug Delivery and Clinical Research Center Limited
InventorPeter Watts
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Abstract
A colonic drug delivery composition is provided and comprises a starch capsule containing a drug, the starch capsule being provided with a coating such that the drug will only be released from the capsule in the colon. The coating may be a pH sensitive material, a redox sensitive material, or a material broken down by specific enzymes or bacteria present in the colon. The drug to be delivered may be one for local action in the colon or a systemically active drug to be absorbed from the colon.
Claims13
A drug delivery composition for delivering a drug to the colonic region comprising a starch capsule containing the drug and wherein the starch capsule is provided with a coating such that the drug is predominantly released from the capsule in the colon and/or terminal ileum.
A drug delivery composition according to any one of the preceding claims wherein the coating has a thickness in the range of 80 μm to 300 μm.
A drug delivery according to any one of the preceding claims wherein the drug is one which acts locally in the colon.
A method of delivering a drug to the colonic region of a human or mammal comprising orally administering a drug delivery composition comprising a starch capsule containing the drug and wherein the starch capsule is provided with a coating such that the drug is predominantly released frown the capsule in the colon and/or terminal ileum.
A method of delivering a vaccine to the lymphoid tissue present in the colon of a human or mammal comprising orally administering a drug delivery composition comprising a starch capsule containing the vaccine and wherein the starch capsule is provided with a coating such that the vaccine is predominantly released from the capsule in the colon and/or terminal ileum.
Dependencies are inferred from the claim text.