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US 2001/0025032 A1Published application
Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
OwnerReid W. Von Borstel, Michael K. Bamatinventors
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Abstract
The subject invention discloses compounds, compositions and methods for treatment and prevention of toxicity due to chemotherapeutic agents and antiviral agents. Disclosed are acylated derivatives of non-methylated pyrimidine nucleosides. These compounds are capable of attenuating damage to the hematopoietic system in animals receiving antiviral or antineoplastic chemotherapy.
Claims36
A method for treating cancer comprising:
- (a) administering a pyrimidine nucleoside analog in a dose at least 1.5 fold greater than the normal maximum tolerated dose, and
- (b) administering a pharmaceutically effective amount of an acyl derivative of a non-methylated pyrimidine nucleoside.
A method for treating cancer comprising:
- (a) administering an inhibitor of the enzyme dihydropyrimidine dehydrogenase;
- (b) administering a 5-fluoropyrimidine or 5-fluoropyrimidine nucleoside analog;
- (c) administering a pharmaceutically effective amount of an acyl derivative of a non-methylated pyrimidine nucleoside.
Dependencies are inferred from the claim text.