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US 2001/0024824 A1Published application
Stem cells and their use in transplantation
AssigneeViacell, Inc.
InventorsPeter Ian Moss, David Martin Walters, Graham Pointer
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AssigneeViacell, Inc.
InventorsPeter Ian Moss, David Martin Walters, Graham Pointer
Estimating the term…
Methods and compositions are described for the treatment of type I insulin-dependent diabetes mellitus and other conditions using newly identified stem cells that are capable of differentiation into a variety of pancreatic islet cells, including insulin-producing beta cells, as well as hepatocytes. Nestin has been identified as a molecular marker for pancreatic stem cells, while cytokeratin-19 serves as a marker for a distinct class of islet ductal cells. Methods are described whereby nestin-positive stem cells can be isolated from pancreatic islets and cultured to obtain further stem cells or pseudo-islet like structures. Methods for ex vivo differentiation of the pancreatic stem cells are disclosed. Methods are described whereby pancreatic stem cells can be isolated, expanded, and transplanted into a patient in need thereof, either allogeneically, isogeneically or xenogenically, to provide replacement for lost or damaged insulin-secreting cells or other cells.
A method of treating a patient with diabetes mellitus, comprising the steps of:
A method of treating a patient with diabetes mellitus, comprising the steps of:
A method of treating a patient with diabetes mellitus, comprising the steps of:
A method of treating a patient with diabetes mellitus, comprising the steps of:
A method of transplanting into a mammal, comprising the steps of:
A method of transplanting into a mammal, comprising the steps of:
A method of transplanting into a mammal, comprising the steps of:
A method of transplanting into a mammal, comprising the steps of:
A transplant graft comprising an isolated, nestin-positive human pancreatic stem cell that is not a neural stem cell.
A method of treating a patient with liver disease, comprising the steps of:
A method of treating a patient with liver disease, comprising the steps of:
A method of treating a patient with liver disease, comprising the steps of:
A method of transplanting into a mammal, comprising the steps of:
A method of transplanting into a mammal, comprising the steps of:
A method of transplanting into a mammal, comprising the steps of:
A transplant graft comprising an isolated, nestin-positive human liver stem cell that is not a neural stem cell.
A transplant graft comprising an isolated, nestin-positive human stem cell that is not a neural stem cell, that is capable of transplant into an animal without causing graft versus host rejection.
Dependencies are inferred from the claim text.