Repair of larynx, trachea, and other fibrocartilaginous tissues
AssigneeCreative BioMolecules, Inc.
InventorsSlobodan Vukicevic, Vladimir Katic, Kuber T. Sampath
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Abstract
Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of osteogenic proteins, and are useful in repairing defects in the larynx, trachea, interarticular menisci, intervertebral discs, ear, nose, ribs and other fibrocartilaginous tissues in a mammal.
Claims56
A method for repairing a defect locus in a nonarticular cartilage tissue of a mammal, the method comprising providing an osteogenic protein in a biocompatible, bioresorbable carrier to the defect locus, thereby inducing the formation of functional replacement cartilage tissue.
An implantable device for repairing a defect in a nonarticular cartilage tissue of a mammal, the device comprising an osteogenic protein disposed in a devitalized cartilage.
An implantable device for repairing a defect in a nonarticular cartilage tissue of a mammal, the device comprising an osteogenic protein disposed in a collagen carrier.
An implantable device for repairing a defect in a nonarticular cartilage tissue of a mammal, the device comprising an osteogenic protein disposed in a carboxymethylcellulose carrier.
A method of promoting chondrogenesis at a defect locus in a mammal, the method comprising providing an osteogenic protein in a devitalized cartilage carrier to the defect locus, wherein the cartilage carrier is configured to fit into the defect locus.
The method of 47, wherein the osteogenic protein comprises an amino acid sequence having at least 70% homology to the C-terminal 102-106 amino acids, including the conserved seven-cysteine domain, of human OP-1.
A method of repairing a defect locus in a ligament in a mammal, the method comprising providing an osteogenic protein in a biocompatible, bioresorbable carrier to the defect locus, thereby inducing the formation of functional replacement ligament tissue.
Dependencies are inferred from the claim text.