Method to produce novel polyketides
OwnerChaitan Khosla, Rembert Pieper +3inventors
InventorsChaitan Khosla, Rembert Pieper, Guanglin Luo, David E. Crane, Camilla Kao
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Abstract
Modified PKS gene clusters which produce novel polyketides in an efficient system in a host cell or in a cell free extract are described.
Claims17
A modified modular polyketide synthase (PKS) comprising at least two modules, wherein said PKS has been modified to prevent its utilization of the native starter unit for said modular PKS.
A PKS gene cluster which encodes a modified PKS wherein said modified PKS has been modified to prevent its utilization of the native starter unit for said modular PKS.
A novel polyketide which has the structure shown as formula 6, 7 or 8 in FIG. 2.
Dependencies are inferred from the claim text.