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US 2001/0024786 A1Published application
Human peroxisomal thioesterase
AssigneeIncyte Pharmaceuticals, Inc.
InventorsJennifer L. Hillman, Purvi Shah, Neil C. Corley
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Abstract
The invention provides a human peroxisomal thioesterase (PxTE) and polynucleotides which identify and encode PxTE. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of PxTE.
Claims39
A purified polypeptide comprising an amino acid sequence selected from the group consisting of:
- a) an amino acid sequence of SEQ ID NO:
- 1,
- b) a naturally-occurring amino acid sequence having at least 90% sequence identity to the sequence of SEQ ID NO:
- 1,
- c) a biologically-active fragment of the amino acid sequence of SEQ ID NO:
- 1, and
- d) an immunogenic fragment of the amino acid sequence of SEQ ID NO:
- 1.
5 more elements
An isolated polynucleotide comprising a sequence selected from the group consisting of:
- a) a polynucleotide sequence of SEQ ID NO:2,
- b) a naturally-occurring polynucleotide sequence having at least 90% sequence identity to the sequence of SEQ ID NO:2,
- c) a polynucleotide sequence complementary to a),
- d) a polynucleotide sequence complementary to b) and
- e) a ribonucleotide equivalent of a)-d).
2 more elements
Dependencies are inferred from the claim text.