Method of screening for pharmaceuticals by detecting cross talk between intracellular signals and intranuclear receptors
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsShigeaki Kato, Jun Yanagisawa
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Abstract
Under the knowledge which two kinds of intracellular signal transfer mechanism of TGF-β super family receptor exist: a pathway via Smad molecule and a pathway via novel MAP kinase such as TAB1 and TAK1, and the knowledge of interaction of Smad molecule with intranuclear receptor or CBP/p300 on the transcription control by Smad molecule, a screening method and a molecular designing method for pharmaceuticals with identified site of action and higher specificity can be accomplished.
Claims13
A method for screening pharmaceuticals comprising detecting cross talk between intracellular signal from TGF-β family receptor and an intranuclear receptor.
A method for screening pharmaceuticals which induce cross talk between intracellular signal from TGF-β family receptor and an intranuclear receptor.
A method for screening pharmaceuticals which inhibit cross talk between intracellular signal from TGF-β family receptor and an intranuclear receptor.
A method for screening pharmaceuticals comprising detecting interaction between an intranuclear receptor and Smad molecule.
A method for screening of pharmaceuticals comprising detecting interaction between a transcription coupling factor and Smad molecule.
A method for screening of pharmaceuticals comprising detecting interaction among an intranuclear receptor, Smad molecule and an transcription coupling factor.
A method for molecular design for pharmaceuticals characterized by using steric structural data of the binding site of Smad molecule with an intranuclear receptor and CPB and/or p300 as a transcription coupling factor.
Dependencies are inferred from the claim text.