Synthetic peptides for the detection of trimethylamine (TMA) and their detection method and device
AssigneeDevelopment Center for Biotechnology
InventorsHeau-Shan Gao, I-Nan Chang, Tzong-Zeng Wu, Ya-Ling Liao, Sung-Sheng Hsiung
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Abstract
The present invention describes a peptide and analogs thereof which is a fragment of an olfactory receptor protein capable of selectively binding to trimethylamine so that they are useful for detecting trimethylamine. The present invention further describes a method and a device for detecting trimethylamine by using the peptide and the analogs thereof.
Claims73
A peptide for detecting trimethylamine, which comprises the following amino acid sequence:
- Cys-Pro-Ser-Ala-Asn-Asn-Ser-Thr-Val-Lys-Glu (SEQ ID NO.1);
- and analogues thereof.
A peptide capable of detecting trimethylamine and binding to a piezoelectric crystal, wherein the peptide comprises a peptide selected from the group consisting of:
- Cys-Pro-Ser-Ala-Asn-Asn-Ser-Thr-Val-Lys-Glu-Gly-Cys-Gly (Peptide I, SEQ ID NO.5);
- Cys-Pro-Ser-Ala-Asn-Asn-Ser-Thr-Gly-Cys-Gly (Peptide II, SEQ ID NO.6);
- Cys-Pro-Ser-Ala-Asn-Asn-Gly-Cys-Gly (Peptide III, SEQ ID NO.7);
- and
- Cys-Asn-Ser-Thr-Val-Lys-Glu-Gly-Cys-Gly (Peptide IV, SEQ ID NO.8).
Dependencies are inferred from the claim text.