Sequences for targeting metastatic cells
AssigneeBaylor College of Medicine
InventorTimothy C. Thompson
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Abstract
The present invention relates to methods for the diagnosis, evaluation and treatment of metastatic diseases using metastatic sequences, such as caveolin, to target metastatic cells. According to the methods of the present invention, certain cancers, including metastatic prostate cancer, may be treated by therapies which suppress expression of the caveolin gene. The present invention relates to biological technologies designed to block the activity of caveolin or the function of caveolae, including vector delivery of antisense caveolin sequences, the use of anti-caveolin antibodies, the use of promoters, and other approaches targeting the expression of caveolin.
Claims25
A method for treating a patient having a metastatic tumor comprising delivering a therapeutically effective amount of an antisense caveolin nucleic acid to said patient.
A method for treating a metastatic disorder comprising administering to a patient having said disorder an effective amount of an anti-caveolin antibody.
A method for evaluating the metastatic potential of a primary prostate tumor comprising:
- contacting a sample of the tumor with an anti-caveolin antibody coupled to a detectable marker;
- and
- determining the amount of antibody bound to the sample.
A method for treating a patient for prostate cancer comprising the steps of:
- suppressing caveolin expression by the prostate cancer;
- and
- reducing the level of androgen in the patient.
An isolated promoter that is specific for expression in metastatic cells.
Dependencies are inferred from the claim text.