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AssigneeAlza Corporation
InventorsAndrew C. Lam, Padmaja Shivanand, Atul D. Ayer, Zahedeh Hatamkhany, Suneel K. Gupta, Diane R. Guinta, Carol A. Christopher, Samuel R. Saks, Lawrence G. Hamel, Jeri D. Wright, Richard G. Weyers
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Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.
A method for treating a condition with a drug indicated for treatment of said condition, the method comprising the step of orally administering a dosage form containing said drug in a pharmaceutically acceptable carrier wherein said dosage form releases said drug from said dosage form at an ascending release rate for an extended time period.
A method for treating ADHD, the method comprising the step of orally administering a dosage form containing a CNS-acting drug in a pharmaceutically acceptable carrier wherein said dosage form releases said CNS-acting drug from said dosage form at an ascending release rate for an extended time period.
A method for effectively treating ADHD for a prolonged therapy period of at least about 10 hours comprising administering methylphenidate in a dosage form that provides release of methylphenidate at an ascending release rate over an extended time period.
A method for providing plasma methylphenidate concentrations that are substantially smoothly ascending over an extended time period comprising administering methylphenidate in a dosage form that provides release of methylphenidate at an ascending release rate over an extended time period.
A dosage form comprising a drug in a pharmaceutically acceptable carrier wherein, following oral administration, said dosage form releases said drug from said dosage form at an ascending release rate for an extended time period.
A dosage form containing a CNS-acting drug in a pharmaceutically acceptable carrier wherein said dosage form, following oral administration, releases said CNS-acting drug from said dosage form at an ascending release rate for an extended time period.
Dependencies are inferred from the claim text.