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US 2001/0012836 A1Published application
Human histone deacetylase gene HD4
OwnerErding Hu, Yuan Zhu +1inventors
InventorsErding Hu, Yuan Zhu, Xuejun Zhu
Life of this patent
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Abstract
HD4 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HD4 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
Claims12
An isolated polypeptide selected from the group consisting of:
- (i) an isolated polypeptide comprising an amino acid sequence selected from the group having at least:
- (a) 70% identity,
- (b) 80% identity;
- (c) 90% identity;
- or
- (d) 95% identity
- to the amino acid sequence of SEQ ID NO:2 over the entire length of SEQ ID NO:2;
- (ii) an isolated polypeptide comprising the amino acid sequence of SEQ ID NO:2 or
- (iii) an isolated polypeptide which is the amino acid sequence of SEQ ID NO:2.
6 more elements
An isolated polynucleotide selected from the group consisting of:
- (i) an isolated polynucleotide comprising a nucleotide sequence encoding a polypeptide that has at least
- (a) 70% identity;
- (b) 80% identity;
- (c) 90% identity;
- or
- (d) 95% identity;
- to the amino acid sequence of SEQ ID NO:2, over the entire length of SEQ ID NO:2;
- (ii) an isolated polynucleotide comprising a nucleotide sequence that has at least:
- (a) 70% identity
- (b) 80% identity;
- (c) 90% identity;
- or
- (d) 95% identity;
- over its entire length to a nucleotide sequence encoding the polypeptide of SEQ ID NO:2;
- (iii) an isolated polynucleotide comprising a nucleotide sequence which has at least:
- (a) 70% identity;
- (b) 80% identity;
- (c) 90% identity;
- or
- (d) 95% identity;
- to that of SEQ ID NO:
- 1 over the entire length of SEQ ID NO:1;
- (iv) an isolated polynucleotide comprising a nucleotide sequence encoding the polypeptide of SEQ ID NO:2;
- (vi) an isolated polynucleotide which is the polynucleotide of SEQ ID NO:1;
- or
- (vi) an isolated polynucleotide obtainable by screening an appropriate library under stringent hybridization conditions with a labeled probe having the sequence of SEQ ID NO:1 or a fragment thereof.;
- or a nucleotide sequence complementary to said isolatedpolynucleotide.
24 more elements
Dependencies are inferred from the claim text.