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US 2001/0012618 A1Published application
2'-O-alkylthioalkyl and 2'-C-alkythioalkyl containing nucleic acids
AssigneeRibozyme Pharmaceuticals, Inc.
InventorsLeonid Beigelman, Alex Karpeisky
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Abstract
A compound having the formula: 1 wherein, R1 represents 2′-O-alkylthioalkyl or 2′-C-alkylthioalkyl; X represents a base or H; Y represents a phosphorus-containing group; and R2 represents H, DMT or a phosphorus-containing group.
Claims12
A compound having the formula:
- 4
- wherein, R1 represents 2′-O-alkylthioalkyl or 2′-C-alkylthioalkyl;
- X represents a base or H;
- Y represents a phosphorus-containing group;
- and R2 represents O, DMT or a phosphorus-containing group.
2 more elements
Method for producing an enzymatic nucleic acid molecule having
- activity to cleave an RNA or single-stranded DNA molecule, comprising the step of forming said enzymatic molecule with at least one position having at its 2′-position an 2′-O-alkylthioalkyl and/or 2′-C-alkylthioalkyl group.
Dependencies are inferred from the claim text.