Arylgycinamide derivatives, methods of producing these substances and pharmaceutical compositions containing such compounds

Arylglycinamide derivatives of general formula I 100

• or the pharmaceutically acceptable salts thereof, wherein
• Ar denotes unsubstituted or mono- to penta-substituted phenyl, or unsubstituted or mono- or di-substituted naphthyl, [in which the substituents of the phenyl and naphthyl independently of each other denote halogen (F, Cl, Br, I), OH, (C1-4)alkyl, O—(C1-4) alkyl, CF3, OCF3 or NR9R10 (wherein R9 and R10 independently of each other denote H, methyl or acetyl)] or Ar is phenyl substituted by —OCH2O— or —O(CH2)2O—;
• R1 and R2 together with the N to which they are bound form a ring of the formula 101
• wherein
• p is 2 or 3,
• X denotes oxygen, N(CH2)nR6 or CR7R8, wherein
• n is 0, 1 or 2,
• R6 is (C3-7)cycloalkyl, phenyl or naphthyl, wherein the phenyl may be mono- to tri-substituted by halogen (F, Cl, Br, I), (C1-4)alkyl, O—(C1-4)alkyl, CF3, OCF3 or NR15R16 (wherein R15 and R16 independently of each other denote H, methyl or acetyl);
• R7 and R8 have one of the following meanings:
• a) R7 and R8 represent H if R3 is unsubstituted or substituted phenyl,
• b) R7 is phenyl, phenyl substituted by 1 to 3 substituents [wherein the substituents independently of one another denote halogen (F, Cl, Br, I), (C1-4)alkyl, O—(C1-4)alkyl, CF3 or OCF3], piperidinyl, 1-methylpiperidinyl, 102
• if R8 is H, —CONH2, —NHC(O)CH3, —N(CH3)C(O)CH3, CN 103
• or
• c) R7 and R8 together form the group 104
• R3 denotes H, (C1-4)alkyl, unsubstituted or mono- to tri-substituted phenyl, wherein the substituents independently of one another represent halogen (F, Cl, Br, I), (C1-4) alkyl, O—(C1-4) alkyl, CF3, OCF3 or NR17R18 (wherein R17 and R18 independently of one another denote H- methyl or acetyl);
• R4 denotes phenyl (C1-4) alkyl or naphthyl (C1-4) alkyl, wherein phenyl may be substituted by 1 to 3 substituents, wherein the substituents independently of one another are halogen (F, Cl, Br, I), (C1-4) alkyl, O—(C1-4) alkyl, CF3, OCF3 or NR19R 20 (wherein R19 and R20 independently of one another denote H, methyl or acetyl);
• and
• R5 denotes H, (C1-4) alkyl, (C3-6) cycloalkyl, CH2COOH, —CH2C(O)NH2, —OH or phenyl (C1-4) alkyl.