Stem cell inhibitor
AssigneeWyeth
InventorsGERARD GRAHAM, IAN PRAGNELL
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Abstract
The present invention provides a Stem Cell Inhibitor (SCI) protein which comprises at least one amino acid alteration from its native form which protein does not significantly aggregate but which retains substantially unaltered stem cell inhibitory activity. The alteration is preferably a conservative subsitution of a charged amino acid residue. Such proteins may be used in treating stem cells in a patient undergoing chemotherapy.
Claims14
A Stem Cell Inhibitor (SCI) protein which comprises at least one amino acid alteration from its native form which protein does not significantly aggregate but which retains substantially unaltered stem cell inhibitory activity.
A protein according to any one of the preceding claims which contains 2 or 3 amino acid alterations.
Dependencies are inferred from the claim text.