Lipid complexes and liposomes of highly insoluble platinum complexes
AssigneePharmacia & Upjohn Company
InventorMATHEW CHERIAN
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Abstract
A pharmaceutical composition comprising a lipid complex or a liposome of a phospholipid and a water-insoluble platinum dicarboxylate and method for the preparation of such compositions are described.
Claims27
A pharmaceutical composition comprising a lipid complex or a liposome of a phospholipid and a water-insoluble complex of a platinum dicarboxylate.
A pharmaceutical composition comprising a complex of diaminocyclohexane-platinum malonate and dimyristoyl phosphatidyl choline (DMPC) and dimyristoyl phosphatidyl glycerol (DMPG), the ratio of DMPC:
- DMPG being about 7:3.
A method for preparing lipid complexes or liposomes of a phospholipid in a non-aqueous solvent and a dicarboxylic acid;
- removing said non-aqueous solvent from said aqueous solution to form a complex of said phospholipid and said water-insoluble complex of a platinum dicarboxylate;
- adding to said aqueous solution a phospholipid in a non-aqueous solvent and a dicarboxylic acid;
- and
- removing said non-aqueous solvent from said aqueous solution to form a complex of said phospholipid and said water-insoluble complex of platinum dicarboxylate.
Dependencies are inferred from the claim text.