Systems and methods for image processing to determine blood flow

A system for decision support for therapy for a patient, the system comprising:

• a data storage device that stores instructions for processing images to determine blood flow information;
• and
• a processor configured to execute the instructions to perform operations comprising:
• segmenting organ data representing an organ of a first patient from a plurality of scan data from a medical scanner, the plurality of scan data representing a volume of the first patient, wherein the segmented organ data comprises data regarding a coronary vasculature of the first patient, wherein the segmenting is image-based segmentation;
• simulating, by a processor, an initial organ-specific physiological model wherein the initial organ-specific physiological model is generated from the segmented organ data and a first treatment of a plurality of different treatments, wherein the plurality of different treatments includes medication-only treatments, interventional treatments, and/or surgical treatments;
• estimating, by the processor, one or more initial uncertainties in the initial organ-specific physiological model;
• generating, by a processor, for each of the one or more initial uncertainties, one or more initial blood flow characteristic values;
• determining, by a processor, at least one statistical variation of the blood flow characteristic values for each of the one or more initial uncertainties;
• simulating, by a processor, a new organ-specific physiological model using a second treatment of the plurality of treatments, wherein the first treatment and the second treatment are different treatments;
• estimating, by the processor, one or more new uncertainties in the new organ-specific physiological model;
• generating, by a processor, for each of the one or more new uncertainties, one or more new blood flow characteristic values;
• and
• providing for display, by a processor, (1) the initial organ-specific physiological model or (2) the new organ-specific physiological model, wherein the initial and new organ-specific physiological models each are a three-dimensional anatomic model of coronary vasculature of the first patient.

A non-transitory computer-readable medium for use on at least one computer system containing computer executable programming instructions for decision support for therapy, the instructions comprising steps for:

• segmenting organ data representing an organ of a first patient from a plurality of scan data from a medical scanner, the plurality of scan data representing a volume of the first patient, wherein the segmented organ data comprises data regarding a coronary vasculature of the first patient, wherein the segmenting is image-based segmentation;
• simulating, by a processor, an initial organ-specific physiological model wherein the initial organ-specific physiological model is generated from the segmented organ data and a first treatment of a plurality of different treatments, wherein the plurality of different treatments includes medication-only treatments, interventional treatments, and/or surgical treatments;
• estimating, by the processor, one or more initial uncertainties in the initial organ-specific physiological model;
• generating, by a processor, for each of the one or more initial uncertainties, one or more initial blood flow characteristic values;
• determining, by a processor, at least one statistical variation of the blood flow characteristic values for each of the one or more initial uncertainties;
• simulating, by a processor, a new organ-specific physiological model using a second treatment of the plurality of treatments, wherein the first treatment and the second treatment are different treatments;
• estimating, by the processor, one or more new uncertainties in the new organ-specific physiological model;
• generating, by a processor, for each of the one or more new uncertainties, one or more new blood flow characteristic values;
• and
• providing for display, by a processor, (1) the initial organ-specific physiological model or (2) the new organ-specific physiological model, wherein the initial and new organ-specific physiological models each are a three-dimensional anatomic model of coronary vasculature of the first patient.