Measurement chamber extension for spectrophotometric characterization of a sterile liquid in a polymer container by NIR- or Raman-spectrophotometry

A measurement chamber extension for a spectrophotometric characterization with a NIR-spectrophotometer or a Raman-spectrophotometer of a liquid in a polymer container comprising a tubular section, wherein the measurement chamber extension comprises:

• an adapter plate having an adapter opening;
• a container holder comprising a receptacle;
• and
• an optical element comprising a mirror;
• wherein the adapter plate is light-tightly connectable to the measurement chamber of the NIR-spectrophotometer or of the Raman-spectrophotometer by its outer contour being adapted to an outer contour of the measurement chamber of the spectrophotometer, and the adapter opening is arranged to encompass a measurement window of the NIR-spectrophotometer or Raman-spectrophotometer to provide exposition of the liquid to a measurement light beam emitted from the measurement chamber of the NIR-spectrophotometer or Raman-spectrophotometer through the measurement window;
• wherein the receptacle of the container holder is configured to arrange the optical element adjacent to a surface of the polymer container containing the liquid providing a loss-free transflection of the measurement light beam from the optical element to a detector of the NIR-spectrophotometer or Raman-spectrophotometer;
• wherein the receptacle is configured to hold the tubular section of the polymer container as to allow a reproducible layer thickness for the transflection measurement;
• wherein the container holder comprises an optical element support structure comprising a light guiding channel, wherein a width of the light guiding channel is adapted to fit with a width of the measurement window of the NIR-spectrophotometer or Raman-spectrophotometer;
• wherein the optical element comprising the mirror comprises a gold layer, and
• wherein the polymer container is selected from:
• a syringe, an infusion pump, a cartridge for an infusion pump, and an infusion bag.