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AssigneeAsymchem Life Science (Tianjin) Co., Ltd.
InventorsHao Hong, Gage James, Na Zhang, Xuecheng Jiao, Fang Liu, Ru Jia, Wenjing Liu
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Provided are a lipase mutant and an application thereof. Specifically, one or more mutations selected from A262H, A338V, V364I, A158P/V, and 1159N are generated on the basis of an amino acid sequence as shown in SEQ ID NO: 1; and compared with a parental lipase, a change in the structure and function of a protein occurs in the lipase mutant, and the stereoselectivity is improved, such that a usage amount of an enzyme is decreased to a certain extent, the post-treatment difficulty is reduced, and the lipase mutant is suitable for industrial production.
A lipase mutant, wherein the lipase mutant comprises:
Dependencies are inferred from the claim text.