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AssigneeUniversity of Delaware
InventorsChad Greco, Thomas Epps, III, Millicent Sullivan
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The present invention provides a nanocomplex comprising at least one agent and a nanocarrier. The agent is bound to the nanocarrier. The nanocarrier comprises at least one cationic polymer responsive to a stimulus, at least one anionic polymer and at least one lipid. The agent is capable of being released from the nanocarrier upon exposure to the stimulus. The released agent is active. The nanocomplex may be used to deliver the agent into cells, in which the agent may be released from the nanocarrier upon exposure of the cells to the stimulus.
A hybrid nanocomplex comprising at least one agent, at least one cationic polymer responsive to a stimulus, at least one anionic polymer, and at least one cationic lipid, wherein the at least one agent is complexed with the at least one cationic lipid to form a lipoplex, wherein the lipoplex is coated by the at least one anionic polymer, wherein the anionic polymer is coated by the cationic polymer, wherein the at least one agent is capable of being released from the hybrid nanocomplex in a human cell upon exposure to the stimulus, wherein at least one agent is a polynucleotide selected from the group consisting of small interfering RNA (siRNA), messenger RNA (mRNA), microRNA (miRNA), small hairpin RNA (shRNA), and combinations thereof, and wherein the released at least one agent is active in the human cell.
Dependencies are inferred from the claim text.