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US 12,767,948 B2Granted
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
AssigneeIonis Pharmaceuticals, Inc.
InventorsSusan M. Freier, Eric E. Swayze
Life of this patent
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Abstract
The present invention provides oligomeric compounds. Certain such oligomeric compounds are useful for hybridizing to a complementary nucleic acid, including but not limited, to nucleic acids in a cell. In certain embodiments, hybridization results in modulation of the amount activity or expression of the target nucleic acid in a cell.
Claims16
A compound comprising:
- a modified oligonucleotide consisting of 16-18 linked nucleosides, wherein the modified oligonucleotide consists of:
- a 5′-wing consisting of 4 linked nucleosides and having the sugar motif B-B-A-A;
- a 3′-wing consisting of 4 linked nucleosides and having the sugar motif A-A-B-B;
- and
- a gap between the 5′-wing and the 3′-wing consisting of 8-10 linked 2′-deoxynucleosides;
- wherein each B is a bicyclic nucleoside and each A is a 2′-substituted nucleoside comprising a substituent at the 2′-position other than H or OH;
- and
- wherein the nucleobase sequence of the modified oligonucleotide is complementary to the nucleobase sequence of a target nucleic acid.
5 more elements
A modified oligonucleotide consisting of 16 linked nucleosides, wherein the modified oligonucleotide comprises:
- a 5′-wing consisting of 4 linked nucleosides and having the sugar motif B-B-A-A;
- a 3′-wing consisting of 4 linked nucleosides and having the sugar motif A-A-B-B;
- and
- a gap between the 5′-wing and the 3′-wing consisting of 8 linked 2′-deoxynucleosides;
- wherein each B is a LNA nucleoside and each A is a 2′-O-methoxyethyl nucleoside;
- and
- wherein the nucleobase sequence of the modified oligonucleotide is complementary to the nucleobase sequence of a target nucleic acid.
4 more elements
Dependencies are inferred from the claim text.