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AssigneeFriedrich-Alexander-Universitat Erlange-Nurnberg
InventorsWolf-Georg Forssmann, Mario Schiffer
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A pharmaceutical composition containing human ribonuclease 1 is disclosed. The molecule according to the invention (or the analogous variants) is suitable for use as a medicament for therapy of renal diseases of various aetiologies. The drug according to the invention causes regeneration of glomerular podocytes. The molecule according to the invention can be further used by analytical determination of blood concentration as a marker of disease progression of renal syndromes and for prognosis and prevention of renal insufficiency as a valuable factor of laboratory medicine.
A medicament for use in the treatment or regeneration of functionally impaired glomerular podocytes, the medicament comprising an aqueous solution, a pharmaceutical excipient and a human pancreatic ribonuclease polypeptide having a sequence identity of 100% with SEQ ID No. 1, wherein the pharmaceutical excipient comprises a bacteriostatic agent, a surfactant comprising polysorbate 20, an isotonic agent comprising mannitol, a stabilizing amino acid effective to stabilize the polypeptide against aggregation or oligomerization, or a mixture thereof, and the medicament is a pharmaceutical composition formulated for parenteral administration.
Dependencies are inferred from the claim text.