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US 12,767,724 B2Granted
Method of treating carcinomatous peritonitis
AssigneesPerseus Proteomics Inc., National University Corporation Gunma University
InventorsFumiko Nomura, Tadashi Matsuura, Lilin Zhang, Yoichi Aikawa, Takayuki Asao, Takehiko Yokobori
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Abstract
It is an object of the present invention to provide a therapeutic drug for carcinomatous peritonitis. According to the present invention, a therapeutic drug for carcinomatous peritonitis which comprises an antibody which recognizes a transferrin receptor, is provided.
Claims7
A method for treating carcinomatous peritonitis in a patient, comprising:
- intraperitoneally or intravenously administering to the patient a therapeutically effective amount of a drug comprising an antibody which recognizes the amino acids at positions 629 to 633 of a human transferrin receptor,
- wherein the antibody is an antibody having a heavy chain first complementarity determining region (VH CDR1), a heavy chain second complementarity determining region (VH CDR2), and a heavy chain third complementarity determining region (VH CDR3), which are as set forth in SEQ ID NOs:
- 1, 2, and 3, respectively, and also having a light chain first complementarity determining region (VL CDR1), a light chain second complementarity determining region (VL CDR2), and a light chain third complementarity determining region (VL CDR3), which are as set forth in SEQ ID NOs:
- 4, 5, and 6, respectively.
1 more element
Dependencies are inferred from the claim text.