Anti-human PD-L1 antibodies and their uses

An anti-PD-L1 antibody or an antigen-binding fragment thereof, comprising complementarity determining regions (CDRs) of a heavy chain variable region and complementarity determining regions of a light chain variable region, wherein

• the heavy-chain variable region comprising HCDR1 having the sequence of SEQ ID NO:
• 2, HCDR2 having the sequence of SEQ ID NO:
• 3, and HCDR3 having the sequence of SEQ ID NO:
• 4, and the light-chain variable region comprising LCDR1 having the sequence of SEQ ID NO:
• 10, LCDR2 having the sequence of SEQ ID NO:
• 11, and LCDR3 having the sequence of SEQ ID NO:
• 12;
• or
• the heavy-chain variable region comprising HCDR1 having the sequence of SEQ ID NO:
• 6, HCDR2 having the sequence of SEQ ID NO:
• 7, and HCDR3 having the sequence of SEQ ID NO:
• 8, and the light-chain variable region comprising LCDR1 having the sequence of SEQ ID NO:
• 14, LCDR2 having the sequence of SEQ ID NO:
• 15, and LCDR3 having the sequence of SEQ ID NO:
• 16.