Anti-Siglec15 antibody and use thereof

An anti-Siglec15 antibody or antigen-binding fragment thereof comprising a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises a heavy chain complementarity-determining region (HCDR) 1, an HCDR2, and an HCDR3, and the light chain variable region comprises a light chain complementarity-determining region (LCDR) 1, an LCDR2, and an LCDR3,

• wherein:
• the heavy chain variable region comprises HCDR1 having the amino acid sequence set forth in SEQ ID NO:
• 6, HCDR2 having the amino acid sequence set forth in SEQ ID NO:
• 7, and HCDR3 having the amino acid sequence set forth in SEQ ID NO:
• 8, and the light chain variable region comprises LCDR1 having the amino acid sequence set forth in SEQ ID NO:
• 9, LCDR2 having the amino acid sequence set forth in SEQ ID NO:
• 10, and LCDR3 having the amino acid sequence set forth in SEQ ID NO:
• 11;
• or
• the heavy chain variable region comprises HCDR1 having the amino acid sequence set forth in SEQ ID NO:
• 6, HCDR2 having the amino acid sequence set forth in SEQ ID NO:
• 12, and HCDR3 having the amino acid sequence set forth in SEQ ID NO:
• 8, and the light chain variable region comprises LCDR1 having the amino acid sequence set forth in SEQ ID NO:
• 13, LCDR2 having the amino acid sequence set forth in SEQ ID NO:
• 10, and LCDR3 having the amino acid sequence set forth in SEQ ID NO:
• 11;
• or
• the heavy chain variable region comprises HCDR1 having the amino acid sequence set forth in SEQ ID NO:
• 14, HCDR2 having the amino acid sequence set forth in SEQ ID NO:
• 15, and HCDR3 having the amino acid sequence set forth in SEQ ID NO:
• 16, and the light chain variable region comprises LCDR1 having the amino acid sequence set forth in SEQ ID NO:
• 17, LCDR2 having the amino acid sequence set forth in SEQ ID NO:
• 18, and LCDR3 having the amino acid sequence set forth in SEQ ID NO:
• 19;
• or
• the heavy chain variable region comprises HCDR1 having the amino acid sequence set forth in SEQ ID NO:
• 20, HCDR2 having the amino acid sequence set forth in SEQ ID NO:
• 21, and HCDR3 having the amino acid sequence set forth in SEQ ID NO:
• 22, and the light chain variable region comprises LCDR1 having the amino acid sequence set forth in SEQ ID NO:
• 23, LCDR2 having the amino acid sequence set forth in SEQ ID NO:
• 24, and LCDR3 having the amino acid sequence set forth in SEQ ID NO:
• 25,
• wherein the amino acid sequences of HCDR1, HCDR2, HCDR3, LCDR1, LCDR2, and LCDR3 are defined according to Kabat.