Cancer vaccines for kidney cancer
AssigneeCureVac Netherlands B.V.
InventorRonald Hans Anton Plasterk
Life of this patent
Estimating the term…
Abstract
The invention relates to the field of cancer, in particular kidney cancer. In particular, it relates to the field of immune system directed approaches for tumor reduction and control. Some aspects of the invention relate to vaccines, vaccinations and other means of stimulating an antigen specific immune response against a tumor in individuals. Such vaccines comprise neoantigens resulting from frameshift mutations that bring out-of-frame sequences of the BAP1, PBRM1, SETD2, and VHL genes in-frame. Such vaccines are also useful for ‘off the shelf’ use.
Claims11
A vaccine or collection of vaccines for treating kidney cancer comprising:
- (i) a peptide, or a collection of tiled peptides, having the amino acid sequence of SEQ ID NO:
- 1, or a fragment comprising at least 10 consecutive amino acids of SEQ ID NO:
- 1, or one or more nucleic acids encoding said peptide or collection of tiled peptides, wherein said peptide is a major histocompatibility complex class I (MHC-class I) binding peptide;
- a peptide, or a collection of tiled peptides, having the amino acid sequence of SEQ ID NO:
- 3, or one or more nucleic acids encoding said peptide or collection of tiled peptides, wherein said peptide is a MHC-class I binding peptide;
- and
- a peptide, or a collection of tiled peptides, having the amino acid sequence of SEQ ID NO:
- 5, or a fragment comprising at least 10 consecutive amino acids of SEQ ID NO:
- 5 or one or more nucleic acids encoding said peptide or collection of tiled peptides, wherein said peptide is a major histocompatibility complex class I (MHC-class I) binding peptide;
- and wherein said vaccine or collection of vaccines further comprises a pharmaceutically acceptable excipient and an adjuvant or a therapeutic agent.
The vaccine or collection of vaccines of 2, wherein said peptides are comprised within the same polypeptide.
Dependencies are inferred from the claim text.