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US 12,767,669 B2Granted
Gallium-salophen antimicrobial compounds and methods of use thereof
AssigneeUniversity of Maryland, Baltimore
InventorsFengtian Xue, Angela Wilks
Life of this patent
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Abstract
Gallium-salophen compounds, and methods of using the same for the treatment of disease are disclosed.
Claims19
A compound of formula (I), or a pharmaceutically acceptable salt, solvate, hydrate, cocrystal, or prodrug thereof:
- wherein in formula (I):
- each R1 is a substituent independently selected at each occurrence from halogen, optionally substituted alkyl, optionally substituted alkylaryl, optionally substituted alkylheteroaryl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted haloalkyl, optionally substituted alkoxy, and optionally substituted heteroaryl;
- each R2 and R3 is a substituent independently selected at each occurrence from halogen, optionally substituted alkyl, optionally substituted alkylaryl, optionally substituted alkylheteroaryl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted haloalkyl, optionally substituted alkoxy, and optionally substituted heteroaryl;
- wherein one R1 and one R2, one R1 and one R3, or one R2 and one R3 may optionally be joined together;
- n is an integer from 0 to 4;
- p is an integer from 0 to 4;
- q is an integer from 0 to 4;
- and
- wherein the compound of formula (I) is limited by at least one of i), ii), or iii);
- i) each R1 is independently —ORa, wherein each Ra is independently selected at each occurrence from the group consisting of optionally substituted alkyl, optionally substituted alkylaryl, optionally substituted alkylcycloalkyl, and optionally substituted alkylheteroaryl;
- ii) each R2 and R3 is independently —ORb or —(CH2) ORb, wherein each Rb is independently selected at each occurrence from the group consisting of optionally substituted alkyl, optionally substituted alkylaryl, optionally substituted alkylcycloalkyl, and optionally substituted alkylheteroaryl;
- and
- iii) one R2 and one R3 join together to form —O(CH2)rO—, wherein r is an integer from 4 to 7.
10 more elements
A compound of formula (II), or a pharmaceutically acceptable salt, solvate, hydrate, cocrystal, or prodrug thereof:
- wherein in formula (II):
- R1 is selected from the group consisting of H, halogen, optionally substituted alkyl, optionally substituted alkylaryl, optionally substituted alkylhetaryl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted haloalkyl, optionally substituted alkoxy, and optionally substituted heteroaryl;
- and
- R2a, R2b, R3a and R3b is each independently selected from the group consisting of H, halogen, optionally substituted alkyl, optionally substituted alkylaryl, optionally substituted alkylhetaryl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted haloalkyl, optionally substituted alkoxy, and optionally substituted heteroaryl;
- and wherein the compound of formula (II) is limited by at least one of i), ii), or iii);
- i) R1 is selected from the group consisting of —OMe, —OEt, —OPr, —OiPr,
- ii) R2a and R2b are each independently selected from the group consisting of H,
- wherein X− is independently at each occurrence selected from Br−, Cl−, and I−;
- or
- iii) R3a and R3b are each independently selected from the group consisting of H
- wherein X− is independently at each occurrence selected from Br−, Cl−, and I−.
8 more elements
A compound is selected from:
Dependencies are inferred from the claim text.