Macrocyclic ligands with pendant chelating moieties and complexes thereof

A compound of the formula:

• wherein
• L1 is:
• wherein
• L1a is selected from substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted biaryl, and substituted or unsubstituted heteroaryl;
• L1b and L1c are independently selected from a bond, C(O)—, substituted or unsubstituted alkyl, and substituted or unsubstituted heteroalkyl;
• RL1 and RL2 are independently selected from H, substituted or unsubstituted alkyl, and substituted or unsubstituted heteroalkyl
• Lx6 is selected from H, a linker to a reactive functional group, and a linker to a targeting moiety;
• L2 is:
• wherein
• L2a, L2b and L2c are independently selected from substituted or unsubstituted alkyl and substituted or unsubstituted heteroalkyl;
• L2d, L2e, L2f and L2g are independently selected from a bond, —C(O)—, substituted or unsubstituted alkyl, and substituted or unsubstituted heteroalkyl;
• and
• RL3 and RL4 are independently selected from hydrogen, substituted or unsubstituted alkyl, and substituted or unsubstituted heteroalkyl
• Ab1 and Ab2 are independently selected:
• Ab1 and Ab2 are independently selected:
• wherein
• R6, R7, and R8 are each independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, halogen, CN, —CF3, —C(O)R17, —SO2NR17R18, —NR17R18, —OR17, —S(O)2R17, —COOR17, —S(O)2OR17, —OC(O)R17, —C(O)NR17R18, —NR17C(O)R18, —NR17SO2R18, and —NO2—;
• R17 and R18 are independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl and substituted or unsubstituted heterocycloalkyl;
• and
• each R1 is independently selected from H and a single negative charge.